"This basically confirms what we've believed to be true," Kelley said. "But this is the first time [the research] has Mens Nike Lebron X Basketball Shoes
Older people are among those at greatest risk for flu complications, like pneumonia. Centers for Disease Control and Prevention said that 98 of every 100,000 seniors were hospitalized with the flu for the week ending Jan. 19.
For the study, which appeared Feb. 6 in the journal Science Translational Medicine, researchers analyzed blood samples from 17 volunteers who'd gotten the flu shot. Four of them were aged 70 or older, while the rest were 8 to 30 years old.
And a better understanding of older people's immune response could help in developing better flu vaccines, according to Pavia, who also chairs the Pandemic Influenza Task Force of the Infectious Diseases Society of America.
Older people may also want to avoid being around others who are sick, and be vigilant for potential flu symptoms, Jiang said. Those include fever, chills, sore throat, headache and body aches.
They used gene sequencing technology to get a "head count" of immune system cells called B cells during the volunteers' peak immune response to the vaccine, explained lead researcher Ning Jenny Jiang, currently an assistant professor at the University of Texas at Austin. The study took place while she was based at Stanford University.
But Jiang's team found that after the flu shot, elderly people had lower numbers of distinct B cell types, compared to young people. That essentially means they had a less diverse array of weapons against the flu.
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"Getting the flu shot is safe, and it's better than doing nothing," said Kelley, who was not involved in the new study. "It's still the best weapon we've got."
Flu Shot May Not Work as Well for Seniors
B cells are important because they produce the antibodies that the immune system launches against invaders, like the flu virus. When B cells are exposed to the dead or weakened virus in a vaccine, they "tweak" their antibody weapons to be more effective against the real virus.
So older adults should keep getting vaccinated every year, according to Nicholas Kelley, a research associate with the Center for Infectious Disease Research and Policy at the University of Minnesota, in Minneapolis.
Experts say the findings essentially confirm what's been believed: The flu shot just doesn't work as well for older immune systems. But they also caution that the vaccine remains the best defense against flu misery.
Both Pavia and Kelley said that ultimately, what's needed is a flu shot that's more effective for seniors and for children younger than 2, Pavia noted.
this technical of a level."
Another expert said the study provides helpful new information for researchers.
"We've known for years that older adults don't respond as well to the flu vaccine," said Dr. Andrew Pavia, chief of pediatric infectious diseases at the University of Utah in Salt Lake City. "This gives us some insights into why."
B cells are already very "specialized" and possibly more resistant to further "tweaks" from the flu vaccine.
There is already a high dose flu vaccine on the market, specifically designed for people age 65 and up. Researchers know it can spur older immune systems to produce more antibodies. One is to get your flu shot early, since it takes about two weeks for the body to build up immunity. In the United States, flu season can begin as early as October.
By Amy NortonWEDNESDAY, Feb. 6 (HealthDay News) Seniors seem to get a weaker boost to their immune system following a flu shot than young people do, a Nike Lebron 11 South Beach small study shows.
"We also noticed that B cells from elderly people had a higher level of mutation, or tweaks, to their antibody coding genes compared to other age groups," Jiang said. That suggests their Nike Zoom Yellow And White
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